Modern hyperthermia for modern radiotherapy

Cancer Centers Development

M&A

Global presence

ALBA

Product lines

Turnkey projects

M&A, Capital injection, JV's

Consulting Services

The SHI Team

Global Presence

Hyperthermia

Radio-biological rationale

Boost up to 10 / 20 Gy or more with no additional toxicity

Heats tumors in the range of 41-43°C for 1 hour
Combined with radiotherapy or chemotherapy
Enhances the effect of radiotherapy & chemotherapy on the tumor, without additional toxicity
Effectively optimize clinical dose-fractionation schedules
1x / 2x a week

HT enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage.

HT increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity.

HT selectively kills radioresistant hypoxic tumor cells.

Datta et al Cancer Treat Rev. 2015;41:742-53
Datta et al Front Oncol 2020;10:819
Issels et al Int J Hyperthermia 2016;32:89-95
Oei et al Adv Drug Deliv Rev 2020;163-164:84-97

Inhibition of DNA damage repair

Reoxygenation

Direct cell killing

Local hyperthermia has also been shown to be capable of inducing systemic anti-tumor immune responses.

Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology

Hyperthermia a clinical dose optimizer

Higher temperature for reoxygenation and more direct cell killing for an effective thermodose escalation.

Achievable as the units allow for a short preparation time and ultrafast and precise Hyperthermia treatment delivery.

cell survival is strongly dependent of thermo-radio sensitization modulation of the linear alfa and beta parameter of the lq model

Hyperthermia dose escalation

High temperature & short time interval

Higher thermo-dose

Short time interval

Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology

Higher temperature / dose

Shorter time interval from RT beam off and HT (>41°C) within 1 hour

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PRECISION

Good thermal contact to avoid artefacts

FAST HYPERTHERMIA TREATMENT DELIVERY

Fast and easy patient positioning

Laser assisted patient registration and precise positioning

HIGH THERMAL DOSE

Realtime extensive dosimetry up to 64 sensors in gtv-ptv

QUALITY ASSURANCE

Sensor position reproducibility

ALBA ON4000D

ALBA 4D

Automatic focusing at tumor coordinates and optimal matching with heated tissue.

Short preparation time of the patient set-up and dedicated tools for applicator positioning as well as the collimation of the center axis of the beam of the applicator with the center of the GTV/PTV.

Superior SAR homogeneity and maximum power deposition in the target result in a high dose escalation.

Dedicated tools in full compliance with the guidelines of the European Society of Hyperthermic Oncology (ESHO) guarantees high level, quality hyperthermia treatment over time.

Sup and semi-deep hyperthermia system

Fully automated deep hyperthermia delivery