Hyperthermia
Radio-biological rationale
Boost up to 10 / 20 Gy or more with no additional toxicity
  • Heats tumors in the range of 41-43°C for 1 hour
  • Combined with radiotherapy or chemotherapy
  • Enhances the effect of radiotherapy & chemotherapy on the tumor, without additional toxicity
  • Effectively optimize clinical dose-fractionation schedules
  • 1x / 2x a week
HT enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage.
HT increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity.
HT selectively kills radioresistant hypoxic tumor cells.
Datta et al Cancer Treat Rev. 2015;41:742-53
Datta et al Front Oncol 2020;10:819
Issels et al Int J Hyperthermia 2016;32:89-95
Oei et al Adv Drug Deliv Rev 2020;163-164:84-97
Inhibition of DNA damage repair
Reoxygenation
Direct cell killing
Local hyperthermia has also been shown to be capable of inducing systemic anti-tumor immune responses.
Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology
Hyperthermia a clinical dose optimizer
Franken, et al., 2013. Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology
Higher thermo-dose
Hyperthermia dose escalation
cell survival is strongly dependent of thermo-radio sensitization modulation of the linear alfa and beta parameter of the lq model
High temperature & short time interval
Achievable as the units allow for a short preparation time and ultrafast and precise Hyperthermia treatment delivery.
Shorter time interval from RT beam off and HT (>41°C) within 1 hour
Higher temperature for reoxygenation and more direct cell killing for an effective thermodose escalation.
Short time interval
Higher temperature / dose
Sup and semi-deep hyperthermia system
Automatic focusing at tumor coordinates and optimal matching with heated tissue.
ALBA ON4000D
PRECISION
01
Superior SAR homogeneity and maximum power deposition in the target result in a high dose escalation.
HIGH THERMAL DOSE
03
Short preparation time of the patient set-up and dedicated tools for applicator positioning as well as the collimation of the center axis of the beam of the applicator with the center of the GTV/PTV.
FAST HYPERTHERMIA TREATMENT DELIVERY
02
Dedicated tools in full compliance with the guidelines of the European Society of Hyperthermic Oncology (ESHO) guarantees high level, quality hyperthermia treatment over time.
QUALITY ASSURANCE
04
Fully automated deep hyperthermia delivery
ALBA 4D
Good thermal contact to avoid artefacts
01
Realtime extensive dosimetry up to 64 sensors in gtv-ptv
02
Fast and easy patient positioning
03
Sensor position reproducibility
04
Laser assisted patient registration and precise positioning
05
Plan2Heat
ALBA Installations
3D calculation in patient GTV/ PTV of: RF power absorption, temperature distribution, TDVH, BED HTRT
Hyperthermia treatment planning
49
33
>200
oncology units
ALBAresearch units
non oncological units
PLAN2heat is a hyperthermia simulation system for research and education purposes only. CE marking for clinical use is in progress.
YOUR THERMO DOSE ESCALATION WITH ALBA PRECISION HYPERTHERMIA
UID CHE-484.560.933 Kanton Zug
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