AVO Light Linear Accelerator Proton System

— No 80 tonnes, 15 m high, cyclotron
— No stray radiation, 60% reduced shielding
— 30% smaller foot print
— Reduced bunker overall cost
— Modular linear accelerator

— Full gantry or rotating seat with built in CT
— Easy rapid installation "in your cellar."
— Micro beam, < 1 mm diameter and less
— High conformal dose quality
— Flash capable at all energies

Standardised building equivalent to only
20 parking spaces

The LIGHT system uses innovative linear accelerators and hence does not require a cyclotron nor a synchrotron to accelerate the protons to the high energy levels needed.

This means that neither the massive infrastructure, nor the extensive shielding associated with old and current forms of proton accelerators are required.

A LARGELY DE-RISKED TECHNOLOGY

A

COMPACT,

INTEGRATED

AND

TURN-KEY

SOLUTION

FOR

PROTON

THERAPY

LIGHT is designed to provide volumetric rescanning with fast energy changes.

Owing to the fast, electronic control of beam energy, and therefore of the depth of dose,
the system will provide 3D dynamic beam patient target alignment, using active range control.

This will improve the accuracy of treating moving targets such as lung and liver and the oesophagus and decrease normal tissue irradiation.

Static dose calculation

1 scan

7 rescans

Dynamic dose delivery

FAST, ELECTRONIC CONTROL OF ENERGY FOR MORE PRECISE DOSE CONFORMITY

FAST,

ELECTRONIC

CONTROL

OF

ENERGY

FOR

MORE

PRECISE

DOSE

CONFORMITY

SMALL BEAM DIMENSIONS FOR GREATER CONFORMITY

LIGHT offers the potential for further development of smaller spot sizes and is thus ideally suited for the novel minibeam treatment.

This kind of therapy provides greater conformity to the target and a reduced entrance dose. It significantly reduces side effects in comparison to photons.

Conventional Intensity Modulated Proton Therapy (IMPT)

Intensity Modulated Minibeam Proton Therapy (IMMPT)

Dose difference IMPT minus IMMPT

DIMENSIONS

GREATER

CONFORMITY

FOR

BEAM

SMALL

Improved patient outcomes:

LIGHT superior proton beam quality delivers more accurate treatments resulting in higher dose to the tumour and reduced dose to healthy tissues

3 proton minibeams delivering Radiosurgery

Detail of proton minibeam on a brain MRI SRS target

2 proton minibeams Radiosurgery

Increased profitability:

— More patients can be treated every year using larger doses (hypofractionation) or Flash

— Reduced infrastructure costs

— Reduced operational costs

Electronic energy control: Rapid painting

Variable spot size: rapidity and accuracy

Minibeams: greatest accuracy

LUNG SBRT

BREAST HYPOFRACTIONATION

PROSTATE SBRT

PROSTATE HYPOFRACTIONATION

1,5 weeks

3,5 weeks

5,5 - 6 weeks

1,5 weeks

6,5 weeks

6,5 weeks

8 weeks

8 weeks

UNKNOWN

HIGH

QUALITY

PROTON

BEAM:

Due to morphologic changes, re-planning during therapy is often needed

Legacy systems do not include diagnostic CT scanners
in their daily workflow – LIGHT® does!

LIGHT offers new, ground up clinical software ideally supporting adaptive, personalised proton therapy care.

Beginning of Treatment

Change During the Treatment Course

Unique CT Scanning Available During the Daily LIGHT® Treatment Session

PROTONTHERAPY

TRUE

MEDICINE

PERSONALISED

FOR

ADAPTIVE

At high dose rates (40-200 Gy/s), a significant sparing of surrounding healthy tissues is observed.

Treatment of a first patient with FLASH-radiotherapy was documented in 2019.

LIGHT could potentially deliver doses up to 40 Gy in less than 0.5 s any target at all energy levels.

Transmission of LIGHT is High At All Energies

conventional cyclotron with ess

light

FLASH

UNLIKE

TECHNOLOGIES

LEGACY

TRUE

EFFECT

LIGHT as the ideal Proton Driver for Immunotherapeutic Effect

The abscopal effect of immunotherapy with conventional RT, irradiates healthy tissues including lymphocytes, which are very sensitive to ionizing radiation

LIGHT's minibeams could provide maximum healthy tissue sparing for minimal damages to lymphocytes

PROTON

IMMUNOTHERAPEUTIC

EFFECT

DRIVER

AS

LIGHT

THE

IDEAL

FOR

LIGHT is compact, modular and easy to install, with potential for system upgrades throughout the life of the machine.

The first commercial system will fit into two existing mews houses in Harley Street, central London!

LIGHT’s modular nature means that multi-room facilities can be built in stages.

ULTRACOMPACT,

CITY-CENTRE

SOLUTION,

IS

NEEDED

WHERE IT

FOCUSED

AN

Adaptable for existing spaces, including small city centre locations

Simplified installation process

LIGHT SYSTEM FEATURES

CUSTOMER BENEFITS

Increases accuracy

Reduces delivery time

Enables conformal treatment of moving targets

Energy modulation pulse by pulse (<5 ms)

Less shielding along the beamline

Dose rate stable at all energies → potentially faster dose delivery

No energy losses

Increased conformity

Minibeams

Treatment time reduction

Ability to adapt to changing reimbursement structure

Hypofractionation and Flash ready

Potential for adaptive radiotherapy

Treatment room integrated with imaging

Software for optimized treatment planning

Reduction of building and land costs

Reduced time between purchase and treatment

Clinical advantage

Increase in patient throughput

Wider indications - more patients

Reduction in building costs

Increase in patient throughput

Clinical advantage

Increase in patient throughput

Higher clinical efficacy

Clinical advantage

Reduction in building costs

Clinical ease of use

LIGHT

SUMMARY

SYSTEM

THE

Energy modulation pulse by pulse (<5 ms)

No energy losses

Minibeams

Hypofractionation and Flash ready

Treatment room integrated with imaging

Blending significantly lower system, facility and operating expenses with well-established reimbursement, AVO LIGHT system removes historical cost and complexity constraints to now put world-class radiosurgery within reach of more providers, and more patients.

— Reducing the cost of bunker design and building

— Reducing the cost of maintenance

— Reducing the cost of implementation

— Reducing Total required time of implementation by 6-12 months

CLINICAL

PERFECT “IN TREATMENT” CONTROL OF THE DOSE

ADAPTIVE TREATMENT TO ANATOMIC CHANGES AND PATIENT MOVES

REDUCED TIME ON THE COUCH

PATIENT COMFORT, REDUCED ANXIETY

BENEFITS

FOR PATIENTS

Perfect “in treatment" control of the dose

FOR HEALTH SYSTEM

Reduced investment and operating cost

FOR THE GOVERNMENT

Proton Therapy democratisation

ECONOMICS

BETTER

ADVANTAGE

AVO Light in the process to get FDA 510(k) clearance

CE is expected in H1 2022.

TOWARD THE FIRST INSTALLATION OF LIGHT

Our priority is to install the LIGHT System close to where the patients live. Our first project in Harley Street, Marylebone, London, UK, is a clear demonstration of this.

The AVO Light sites

England, London
The London Clinic (& Howard de Walden)

Cyprus, Limassol
The Mediterranean Hospital

England, University Hospitals Birmingham NHS Foundation Trust

Global
presence

Being a global group means that we know the challenges the world is facing and adapt to different markets requirements. We help understanding and solving your specific local challenges

Where
you can find us