AVO Light Linear Accelerator Proton System
AVO LIGHT system is designed to deliver superior clinical effectiveness at a competitive cost.
In addition, its modular accelerator construction allows for easier installation at any site.
AVO Light is the first non cyclotron non synchrotron, linear accelerator Proton System
New generation Proton Therapy
COMPACT,
INTEGRATED
TURN-KEY
FOR
PROTON
THERAPY
SOLUTION
AND
A
A LARGELY DE-RISKED TECHNOLOGY
— No 80 tonnes, 15 m high, cyclotron
— No stray radiation, 60% reduced shielding
— 30% smaller foot print
— Reduced bunker overall cost
— Modular linear accelerator
— No stray radiation, 60% reduced shielding
— 30% smaller foot print
— Reduced bunker overall cost
— Modular linear accelerator
— Full gantry or rotating seat with built in CT
— Easy rapid installation "in your cellar."
— Micro beam, < 1 mm diameter and less
— High conformal dose quality
— Flash capable at all energies
— Easy rapid installation "in your cellar."
— Micro beam, < 1 mm diameter and less
— High conformal dose quality
— Flash capable at all energies
The LIGHT system uses innovative linear accelerators and hence does not require a cyclotron nor a synchrotron to accelerate the protons to the high energy levels needed.
This means that neither the massive infrastructure, nor the extensive shielding associated with old and current forms of proton accelerators are required.
This means that neither the massive infrastructure, nor the extensive shielding associated with old and current forms of proton accelerators are required.
Standardised building equivalent to only
20 parking spaces
20 parking spaces
CONTROL
FOR
DOSE
CONFORMITY
MORE
PRECISE
ENERGY
OF
ELECTRONIC
FAST,
FAST, ELECTRONIC CONTROL OF ENERGY FOR MORE PRECISE DOSE CONFORMITY
LIGHT is designed to provide volumetric rescanning with fast energy changes.
Owing to the fast, electronic control of beam energy, and therefore of the depth of dose,
the system will provide 3D dynamic beam patient target alignment, using active range control.
This will improve the accuracy of treating moving targets such as lung and liver and the oesophagus and decrease normal tissue irradiation.
Owing to the fast, electronic control of beam energy, and therefore of the depth of dose,
the system will provide 3D dynamic beam patient target alignment, using active range control.
This will improve the accuracy of treating moving targets such as lung and liver and the oesophagus and decrease normal tissue irradiation.
Static dose calculation
Dynamic dose delivery
1 scan
7 rescans
SMALL BEAM DIMENSIONS FOR GREATER CONFORMITY
LIGHT offers the potential for further development of smaller spot sizes and is thus ideally suited for the novel minibeam treatment.
This kind of therapy provides greater conformity to the target and a reduced entrance dose. It significantly reduces side effects in comparison to photons.
This kind of therapy provides greater conformity to the target and a reduced entrance dose. It significantly reduces side effects in comparison to photons.
Conventional Intensity Modulated Proton Therapy (IMPT)
Intensity Modulated Minibeam Proton Therapy (IMMPT)
Dose difference IMPT minus IMMPT
DIMENSIONS
GREATER
CONFORMITY
FOR
BEAM
SMALL
UNKNOWN HIGH QUALITY PROTON BEAM:
UNKNOWN
QUALITY
BEAM:
PROTON
HIGH
Improved patient outcomes:
LIGHT superior proton beam quality delivers more accurate treatments resulting in higher dose to the tumour and reduced dose to healthy tissues
LIGHT superior proton beam quality delivers more accurate treatments resulting in higher dose to the tumour and reduced dose to healthy tissues
Increased profitability:
— More patients can be treated every year using larger doses (hypofractionation) or Flash
— Reduced infrastructure costs
— Reduced operational costs
— More patients can be treated every year using larger doses (hypofractionation) or Flash
— Reduced infrastructure costs
— Reduced operational costs
Electronic energy control: Rapid painting
Variable spot size: rapidity and accuracy
Minibeams: greatest accuracy
Variable spot size: rapidity and accuracy
Minibeams: greatest accuracy
3 proton minibeams delivering Radiosurgery
Detail of proton minibeam on a brain MRI SRS target
2 proton minibeams Radiosurgery
LUNG SBRT
1,5 weeks
6,5 weeks
3,5 weeks
6,5 weeks
5,5 - 6 weeks
8 weeks
1,5 weeks
8 weeks
BREAST HYPOFRACTIONATION
PROSTATE SBRT
PROSTATE HYPOFRACTIONATION
Due to morphologic changes, re-planning during therapy is often needed
Legacy systems do not include diagnostic CT scanners
in their daily workflow – LIGHT® does!
LIGHT offers new, ground up clinical software ideally supporting adaptive, personalised proton therapy care.
Legacy systems do not include diagnostic CT scanners
in their daily workflow – LIGHT® does!
LIGHT offers new, ground up clinical software ideally supporting adaptive, personalised proton therapy care.
Beginning of Treatment
Change During the Treatment Course
Unique CT Scanning Available During the Daily LIGHT® Treatment Session
PROTONTHERAPY
TRUE
MEDICINE
PERSONALISED
FOR
ADAPTIVE
At high dose rates (40-200 Gy/s), a significant sparing of surrounding healthy tissues is observed.
Transmission of LIGHT is High At All Energies
conventional cyclotron with ess
light
LIGHT could potentially deliver doses up to 40 Gy in less than 0.5 s any target at all energy levels.
Treatment of a first patient with FLASH-radiotherapy was documented in 2019.
FLASH
EFFECT
UNLIKE
TECHNOLOGIES
LEGACY
TRUE
LIGHT as the ideal Proton Driver for Immunotherapeutic Effect
The abscopal effect of immunotherapy with conventional RT, irradiates healthy tissues including lymphocytes, which are very sensitive to ionizing radiation
LIGHT's minibeams could provide maximum healthy tissue sparing for minimal damages to lymphocytes
LIGHT's minibeams could provide maximum healthy tissue sparing for minimal damages to lymphocytes
PROTON
IMMUNOTHERAPEUTIC
EFFECT
DRIVER
FOR
AS
THE
IDEAL
LIGHT
LIGHT is compact, modular and easy to install, with potential for system upgrades throughout the life of the machine.
The first commercial system will fit into two existing mews houses in Harley Street, central London!
LIGHT’s modular nature means that multi-room facilities can be built in stages.
The first commercial system will fit into two existing mews houses in Harley Street, central London!
LIGHT’s modular nature means that multi-room facilities can be built in stages.
ULTRACOMPACT,
CITY-CENTRE
SOLUTION,
IS
NEEDED
WHERE IT
FOCUSED
AN
LIGHT SYSTEM FEATURES
CUSTOMER BENEFITS
Adaptable for existing spaces, including small city centre locations
Simplified installation process
Simplified installation process
Reduction of building and land costs
Reduced time between purchase and treatment
Reduced time between purchase and treatment
Modularity & Compactness
Modularity & Compactness
Increases accuracy
Reduces delivery time
Enables conformal treatment of moving targets
Reduces delivery time
Enables conformal treatment of moving targets
Clinical advantage
Increase in patient throughput
Wider indications - more patients
Increase in patient throughput
Wider indications - more patients
Less shielding along the beamline
Dose rate stable at all energies → potentially faster dose delivery
Dose rate stable at all energies → potentially faster dose delivery
Reduction in building costs
Increase in patient throughput
Increase in patient throughput
Increased conformity
Clinical advantage
Treatment time reduction
Ability to adapt to changing reimbursement structure
Ability to adapt to changing reimbursement structure
Increase in patient throughput
Higher clinical efficacy
Higher clinical efficacy
Potential for adaptive radiotherapy
Clinical advantage
Reduction in building costs
Reduction in building costs
Software for optimized treatment planning
Clinical ease of use
Energy modulation pulse by pulse (<5 ms)
Energy modulation pulse by pulse (<5 ms)
No energy losses
No energy losses
Minibeams
Minibeams
Hypofractionation and Flash ready
Hypofractionation and Flash ready
Treatment room integrated with imaging
Treatment room integrated with imaging
LIGHT
SUMMARY
SYSTEM
THE
ECONOMICS
CLINICAL
ADVANTAGE
BENEFITS
Blending significantly lower system, facility and operating expenses with well-established reimbursement, AVO LIGHT system removes historical cost and complexity constraints to now put world-class radiosurgery within reach of more providers, and more patients.
PERFECT “IN TREATMENT” CONTROL OF THE DOSE
FOR PATIENTS
Perfect “in treatment" control of the dose
Perfect “in treatment" control of the dose
ADAPTIVE TREATMENT TO ANATOMIC CHANGES AND PATIENT MOVES
FOR HEALTH SYSTEM
Reduced investment and operating cost
Reduced investment and operating cost
REDUCED TIME ON THE COUCH
FOR THE GOVERNMENT
Proton Therapy democratisation
Proton Therapy democratisation
PATIENT COMFORT, REDUCED ANXIETY
— Reducing the cost of bunker design and building
— Reducing the cost of maintenance
— Reducing the cost of implementation
— Reducing Total required time of implementation by 6-12 months
— Reducing the cost of maintenance
— Reducing the cost of implementation
— Reducing Total required time of implementation by 6-12 months
BETTER
AVO Light in the process to get FDA 510(k) clearance
The AVO Light sites
Global
presence
presence
Where
you can find us
you can find us
TOWARD THE FIRST INSTALLATION OF LIGHT
Our priority is to install the LIGHT System close to where the patients live. Our first project in Harley Street, Marylebone, London, UK, is a clear demonstration of this.
Our priority is to install the LIGHT System close to where the patients live. Our first project in Harley Street, Marylebone, London, UK, is a clear demonstration of this.
England, London
The London Clinic (& Howard de Walden)
The London Clinic (& Howard de Walden)
Cyprus, Limassol
The Mediterranean Hospital
The Mediterranean Hospital
England, University Hospitals Birmingham NHS Foundation Trust
CE is expected in H1 2022.
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